Ghrelin signalling in AgRP neurons links metabolic state to the sensory regulation of AgRP neural activity

• Main Authors: Wang Lok So (Author), Jiachen Hu (Author), Lotus Jeffs (Author), Harry Dempsey (Author), Sarah H. Lockie (Author), Jeffrey M. Zigman (Author), Romana Stark (Author), Alex Reichenbach (Author), Zane B. Andrews (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The sensory detection of food and food cues suppresses Agouti related peptide (AgRP) neuronal activity prior to consumption with greatest suppression occurring in response to highly caloric food or interoceptive energy need. However, the interoceptive mechanisms priming an appropriate AgR...