Therapy with 2'-O-Me Phosphorothioate Antisense Oligonucleotides Causes Reversible Proteinuria by Inhibiting Renal Protein Reabsorption
Antisense oligonucleotide therapy has been reported to be associated with renal injury. Here, the mechanism of reversible proteinuria was investigated by combining clinical, pre-clinical, and in vitro data. Urine samples were obtained from Duchenne muscular dystrophy (DMD) patients treated with dris...
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Main Authors: | Manoe J. Janssen (Author), Tom T.G. Nieskens (Author), Tessa A.M. Steevels (Author), Pedro Caetano-Pinto (Author), Dirk den Braanker (Author), Melissa Mulder (Author), Yolanda Ponstein (Author), Shaun Jones (Author), Rosalinde Masereeuw (Author), Cathaline den Besten (Author), Martijn J. Wilmer (Author) |
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Format: | Book |
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Elsevier,
2019-12-01T00:00:00Z.
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