Enalapril and Enalaprilat Pharmacokinetics in Children with Heart Failure Due to Dilated Cardiomyopathy and Congestive Heart Failure after Administration of an Orodispersible Enalapril Minitablet (LENA-Studies)

• Main Authors: Stephanie Laeer (Author), Willi Cawello (Author), Bjoern B. Burckhardt (Author), László Ablonczy (Author), Milica Bajcetic (Author), Johannes M. P. J. Breur (Author), Michiel Dalinghaus (Author), Christoph Male (Author), Saskia N. de Wildt (Author), Jörg Breitkreutz (Author), Muhammed Faisal (Author), Anne Keatley-Clarke (Author), Ingrid Klingmann (Author), Florian B. Lagler (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Angiotensin-converting enzyme inhibitors (ACEI), such as enalapril, are a cornerstone of treatment for pediatric heart failure which is still used off-label. Using a novel age-appropriate formulation of enalapril orodispersible minitablets (ODMTs), phase II/III open-label, multicenter pharmacokineti...