Study Protocol: Randomised Controlled Trial Assessing the Efficacy of Strategies Involving Self-Sampling in Cervical Cancer Screening

• Main Authors: Caroline Lefeuvre (Author), Hélène De Pauw (Author), Anne-Sophie Le Duc Banaszuk (Author), Adeline Pivert (Author), Alexandra Ducancelle (Author), Franck Rexand-Galais (Author), Marc Arbyn (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1661-8564; 10.3389/ijph.2022.1604284
• Keywords: cervical cancer; screening coverage; under-screened women; urinary self-sampling; vaginal self-sampling; cancer screening test; Public aspects of medicine; RA1-1270
• Source: International Journal of Public Health, Vol 67 (2022)

Objectives: The cervical cancer screening coverage remains moderate (60%) in France. The aim of the study is to evaluate the efficacy of two experimental invitation strategies (offer of urine or vaginal self-sampling kits) to reach under-screened populations and compare them with the current invitation strategy in rural departments (low medical density and low participation rate) in France.Methods: The study is a randomised controlled trial with three arms: a control arm (conventional invitation letter) and two experimental arms (mailing of a urine or vaginal self-sampling kit). The target population includes women aged 30-65 years, who had no screening test recorded since more than 4 years and who did not respond to an invitation letter within 12 months before. The primary outcome measure is the participation rate in each arm. A team of psychologists will also investigate attitudes and experiences by semi-structured/focus-group interviews with voluntary CapU4 participants and with health professionals.Result and conclusion: CapU4 will identify effective strategies to reach women not responding to current screening invitations and will generate information about acceptance of self-sampling among women and health professionals.