An innovative strategy to investigate microbial protein modifications in a reliable fast and sensitive way: A therapy oriented proof of concept based on UV-C irradiation of SARS-CoV-2 spike protein

• Main Authors: Sergio Strizzi (Author), Letizia Bernardo (Author), Pasqualina D'Ursi (Author), Chiara Urbinati (Author), Andrea Bianco (Author), Fiona Limanaqi (Author), Andrea Manconi (Author), Maria Milanesi (Author), Alberto Macchi (Author), Dario Di Silvestre (Author), Adalberto Cavalleri (Author), Giovanni Pareschi (Author), Marco Rusnati (Author), Mario Clerici (Author), PierLuigi Mauri (Author), Mara Biasin (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The characterization of modifications of microbial proteins is of primary importance to dissect pathogen lifecycle mechanisms and could be useful in identifying therapeutic targets. Attempts to solve this issue yielded only partial and non-exhaustive results. We developed a multidisciplinary approac...