Home-Applied Dual-Light Photodynamic Therapy in the Treatment of Stable Chronic Periodontitis (HOPE-CP)-Three-Month Interim Results

• Main Authors: Saila Pakarinen (Author), Riitta K. T. Saarela (Author), Hannamari Välimaa (Author), Anna Maria Heikkinen (Author), Esko Kankuri (Author), Marja Noponen (Author), Heikki Alapulli (Author), Taina Tervahartiala (Author), Ismo T. Räisänen (Author), Timo Sorsa (Author), Tommi Pätilä (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

A single-site, randomized clinical trial was designed to determine the efficacy of regular home use of Lumoral^® dual-light antibacterial aPDT in periodontitis patients. For the study, 200 patients were randomized to receive non-surgical periodontal treatment (NSPT), including standardized hygiene instructions and electric toothbrush, scaling and root planing, or NSPT with adjunctive Lumoral^® treatment. A complete clinical intraoral examination was conducted in the beginning, at three months, and at six months. This report presents the three-month results of the first 59 consecutive randomized subjects. At three months, bleeding on probing (BOP) was lower in the NSPT + Lumoral^®-group than in the NSPT group (<i>p</i> = 0.045), and more patients in the NSPT + Lumoral^®-group had their BOP below 10% (54% vs. 22%, respectively, <i>p</i> = 0.008). In addition, patients in the NSPT + Lumoral^®-group improved their oral hygiene by visible-plaque-index (<i>p</i> = 0.0003), while the NSPT group showed no statistical improvement compared to the baseline. Both groups significantly reduced the number of deep periodontal pockets, but more patients with a reduction in their deep pocket number were found in the NSPT + Lumoral^® group (92% vs. 63%, <i>p</i> = 0.02). Patients whose number of deep pockets was reduced by 50% or more were also more frequent in the NSPT + Lumoral^®-group (71% vs. 33%, <i>p</i> = 0.01). Patients with initially less than ten deep pockets had fewer deep pockets at the three-month follow-up in the Lumoral^® group (<i>p</i> = 0.01). In conclusion, adjunctive use of Lumoral^® in NSPT results in improved treatment outcomes at three months post-therapy.

Item Description

10.3390/dj10110206
2304-6767