Nontargeted Metabolomics by High-Resolution Mass Spectrometry to Study the In Vitro Metabolism of a Dual Inverse Agonist of Estrogen-Related Receptors β and γ, DN203368

• Main Authors: Sin-Eun Kim (Author), Seung-Bae Ji (Author), Euihyeon Kim (Author), Minseon Jeong (Author), Jina Kim (Author), Gyung-Min Lee (Author), Hyung-Ju Seo (Author), Subin Bae (Author), Yeojin Jeong (Author), Sangkyu Lee (Author), Sunghwan Kim (Author), Taeho Lee (Author), Sung Jin Cho (Author), Kwang-Hyeon Liu (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

DN203368 ((<i>E</i>)-3-[1-(4-[4-isopropylpiperazine-1-yl]phenyl) 3-methyl-2-phenylbut-1-en-1-yl] phenol) is a 4-hydroxy tamoxifen analog that is a dual inverse agonist of estrogen-related receptor β/γ (ERRβ/γ). ERRγ is an orphan nuclear receptor that plays an important role in developmen...