ASSESSMENT OF RILMENIDINE EFFICIENCY IN PATIENTS WITH ARTERIAL HYPERTENSION WITH DETERIORATION OF DAILY PROFILE OF BLOOD PRESSURE

• Main Authors: P. P. Tikhonov (Author), L. A. Sokolova (Author)
• Format: Book
• Published: Столичная издательская компания, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1819-6446; 2225-3653; 10.1234/1819-6446-2005-2-14-19
• Keywords: артериальная гипертензия; суточный профиль АД; рилменидин; Therapeutics. Pharmacology; RM1-950; Diseases of the circulatory (Cardiovascular) system; RC666-701
• Source: Рациональная фармакотерапия в кардиологии, Vol 1, Iss 2, Pp 14-19 (2015)

<p><strong>Aim.</strong> To estimate an efficiency and tolerability of rilmenidine in hypertensive patients with different types of blood pressure (BP) daily profile - dipper and non-dipper.</p><p><strong>Methods.</strong> 23 patients with essential hypertension (EH), I-II stages, were included into the study. They were treated with rilmeneidine 1 mg daily during one month. Ambulatory BP monitoring (ABPM) and office BP measurements were made before and after the treatment. Based on ABPM results all patients were divided into two groups: with adequate decrease of BP at nighttime (dipper, D), and with insufficient decrease of BP at nighttime (non-dipper, ND).</p><p><strong>Results.</strong> One month rilmenidine monotherapy resulted in BP normalization in 52% of patients. Decrease in 24-hour BP, daytime and nighttime BP, burden with BP and BP variability during daytime was observed in both groups. A distinction in rilmenidine influence on BP daily index was revealed: initially normal BP daily index didn't change in D group, while initially decreased BP daily index increased in ND group. Rilmenidine reduced the speed of morning BP rise in patients of ND group.</p><p><strong>Conclusion.</strong> Results of the study testify efficiency and satisfactory tolerability of monotherapy with rilmenidine 1 mg daily in patients with EH of I-II stages. For patients with insufficient decrease in BP during nighttime rilmenidine provides normalization of BP daily profile intensifying BP night decrease and reducing the speed of morning BP rise.</p>