CRIF1 Deficiency Increased Homocysteine Production by Disrupting Dihydrofolate Reductase Expression in Vascular Endothelial Cells

• Main Authors: Ikjun Lee (Author), Shuyu Piao (Author), Seonhee Kim (Author), Harsha Nagar (Author), Su-Jeong Choi (Author), Byeong Hwa Jeon (Author), Sang-Ha Oh (Author), Kaikobad Irani (Author), Cuk-Seong Kim (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Elevated plasma homocysteine levels can induce vascular endothelial dysfunction; however, the mechanisms regulating homocysteine metabolism in impaired endothelial cells are currently unclear. In this study, we deleted the essential mitoribosomal gene CR6 interacting factor 1 (CRIF1) in human umbili...