Antibiotic associated diarrhea in outpatient pediatric antibiotic therapy

• Main Authors: Sevgen Tanır Basaranoğlu (Author), Ayşe Karaaslan (Author), Enes Salı (Author), Ergin Çiftçi (Author), Zeynep Gökçe Gayretli Aydın (Author), Bilge Aldemir Kocabaş (Author), Cemil Kaya (Author), Semra Şen Bayturan (Author), Soner Sertan Kara (Author), Dilek Yılmaz Çiftdoğan (Author), Ümmühan Çay (Author), Hacer Gundogdu Aktürk (Author), Melda Çelik (Author), Halil Ozdemir (Author), Ayper Somer (Author), Tijen Diri (Author), Ahmet Sami Yazar (Author), Murat Sütçü (Author), Hasan Tezer (Author), Eda Karadag Oncel (Author), Manolya Kara (Author), Solmaz Çelebi (Author), Aslınur Özkaya Parlakay (Author), Sabahat Karakaşlılar (Author), Emin Sami Arısoy (Author), Gönül Tanır (Author), Tuğçe Tural Kara (Author), İlker Devrim (Author), Tuğba Erat (Author), Kübra Aykaç (Author), Özge Kaba (Author), Şirin Güven (Author), Edanur Yeşil (Author), Ayşe Tekin Yılmaz (Author), Sevgi Yaşar Durmuş (Author), İlknur Çağlar (Author), Fatih Günay (Author), Metehan Özen (Author), Ener Çağrı Dinleyici (Author), Ateş Kara (Author)
• Format: Book
• Published: BMC, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.1186/s12887-023-03939-w; 1471-2431
• Keywords: Antibiotic-associated diarrhea; Outpatient clinics; Amoxicillin-clavulanate; Cephalosporins; Phenoxymethyl penicillins; Macrolides; Pediatrics; RJ1-570
• Source: BMC Pediatrics, Vol 23, Iss 1, Pp 1-9 (2023)

Abstract Background Antibiotic-associated diarrhea is one of the most frequent side effects of antimicrobial therapy. We assessed the epidemiological data of antibiotic-associated diarrhea in pediatric patients in our region. Methods The prospective multi-center study included pediatric patients who were initiated an oral antibiotic course in outpatient clinics and followed in a well-established surveillance system. This follow-up system constituded inclusion of patient by the primary physician, supply of family follow-up charts to the family, passing the demographics and clinical information of patient to the Primary Investigator Centre, and a close telephone follow-up of patients for a period of eight weeks by the Primary Investigator Centre. Results A result of 758 cases were recruited in the analysis which had a frequency of 10.4% antibiotic-associated diarrhea. Among the cases treated with amoxicillin-clavulanate 10.4%, and cephalosporins 14.4% presented with antibiotic-associated diarrhea. In the analysis of antibiotic-associated diarrhea occurrence according to different geographical regions of Turkey, antibiotic-associated diarrhea episodes differed significantly (p = 0.014), particularly higher in The Eastern Anatolia and Southeastern Anatolia. Though most commonly encountered with cephalosporin use, antibiotic-associated diarrhea is not a frequent side effect. Conclusion This study on pediatric antibiotic-associated diarrhea displayed epidemiological data and the differences geographically in our region.