Inflammasome genes polymorphisms and susceptibility to gout. Is there a link?

• Main Authors: Denise Clavijo-Cornejo (Author), Alberto López-Reyes (Author), Esteban Cruz-Arenas (Author), Leonor Jacobo-Albavera (Author), Daniel Rivera-Tlaltzicapa (Author), Adriana Francisco-Balderas (Author), Mayra Domínguez-Pérez (Author), Pablo Romero-Morelos (Author), Janitzia Vázquez-Mellado (Author), Luis H. Silveira (Author), Carlos Pineda (Author), Gabriela Martínez-Nava (Author), Marwin Gutierrez (Author)
• Format: Book
• Published: Permanyer, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Background: The inflammatory response in gout disease is induced by the activation of NLR family pyrin domain-containing 3 (NLPR3) signaling pathway mediated by IL-1β release. Objective: The objective of the study was to determine the association between single nucleotide polymorphisms (SNPs) within NLRP3 inflammasome genes and gout susceptibility. Methods: Mexican patients with gout from the National Rehabilitation Institute and General Hospital of Mexico were enrolled. A healthy control group was also included. We analyzed the frequency and allelic distribution of eight SNPs from seven different genes within the NLRP3 inflammasome signaling pathway: TLR4 rs2149356, CD14 rs2569190, NLRP3 rs3806268, NLRP3 rs10754558, CARD8 rs2043211, IL-1β rs1143623, P2RX7 rs3751142, and PPARGC1B rs45520937 SNPs. Results: We found that the SNP rs45520937 of PPARGC1B was associated with the risk of developing gout when it was analyzed using the dominant model (Odds ratio [OR] = 2.30; 95% confidence interval [CI]: 1.09-4.86; p = 0.030), and it is proposed that the adaptor molecule CD14 rs2569190 polymorphism could be associated with a lower risk of gout under an additive model (OR= 0.41;95% CI: 0.16-1.05; p = 0.064). No significant associations were identified for the remaining SNPs. Conclusion: Our findings suggest that the PPARGC1B rs45520937 SNP is associated with gout susceptibility.

Item Description

10.24875/RIC.21000603
0034-8376
2564-8896