Association of vitamin D receptor polymorphisms with the risk of prostate cancer in the Han population of Southern China

• Main Authors: Weng Zhiliang (Author), Wei Jia (Author), Lu Hong (Author), Ji Jingzhang (Author), Yu Bin (Author), Ge Jianrong (Author), Yu Yaping (Author), Bai Yongheng (Author), Tao Zhihua (Author), Lu Jianxin (Author)
• Format: Book
• Published: BMC, 2009-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<p>Abstract</p> <p>Background</p> <p>Molecular epidemiological studies have shown that gene polymorphisms of vitamin D receptor (<it>VDR</it>) are associated with prostate cancer risks. However, previous results from many molecular studies remain inconsistent.</p> <p>Methods</p> <p>Blood samples were collected from 122 prostate cancer patients and 130 age-matched control subjects in the Han population of Southern China. The differences of <it>VDR </it>gene polymorphism between cancer cases and controls were determined by PCR-RFLP, examiming <it>Fok</it>I (exon 2), <it>Bsm</it>I, <it>Tru9</it>I, <it>Apa</it>I (intron 9), and <it>Taq</it>I (exon 9). Associations between the <it>VDR </it>gene polymorphism and prostate cancer risk were calculated in an unconditional logistic regression model. Linkage disequilibrium and haplotypes were analyzed with the SHEsis software.</p> <p>Results</p> <p>Of five polymorphisms, <it>Bsm</it>I was shown to associate with prostate cancer, while <it>Fok</it>I, <it>Tru9</it>I, <it>Apa</it>I, and <it>Taq</it>I did not show any significant association. After adjustment for age, the <it>Bsm</it>I '<it>B</it>' allele was associated with an almost 1/3-fold risk (OR = 0.35, 95%CI: 0.15-0.80) of the occurrence of prostate cancer, a 1/5-fold risk (OR = 0.20, 95%CI: 0.06-0.68) of poorly differentiated prostate cancer, and a 1/10-fold risk (OR = 0.10, 95%CI: 0.01-0.78) of aggressive prostate cancer compared with the '<it>b</it>' allele, especially among older men (>71 years). In addition, haplotype analysis revealed that the <it>'F-b-U-A-T</it>' was more frequent found in cases than in controls (3.4% <it>vs </it>0.0%, <it>P </it>= 0.0035), while the frequency of haplotype '<it>F-B-U-a-T</it>' was 0.8% in cases, significantly lower than in controls (3.9%, <it>P </it>= 0.019).</p> <p>Conclusion</p> <p>Our experiments provide evidences that genetic polymorphisms in the <it>VDR </it>gene may be potential risk factors for prostate cancer in the Han population of southern China and the susceptibility to prostate cancer is associated with ethnicity and geographic location.</p>

Item Description

10.1186/1471-2350-10-125
1471-2350