Association between clinical variables related to asthma in schoolchildren born with very low birth weight with and without bronchopulmonary dysplasia

• Main Authors: Emília da Silva Gonçalves (Author), Francisco Mezzacappa-Filho (Author), Silvana Dalge Severino (Author), Maria Ângela Gonçalves de Oliveira Ribeiro (Author), Fernando Augusto de Lima Marson (Author), Andre Moreno Morcilo (Author), Adyléia Aparecida Dalbo Contrera Toro (Author), José Dirceu Ribeiro (Author)
• Format: Book
• Published: Sociedade de Pediatria de São Paulo.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1984-0462; 10.1016/j.rppede.2016.03.005
• Keywords: Asthma; Bronchopulmonary dysplasia; Preterm birth; Pediatrics; RJ1-570
• Source: Revista Paulista de Pediatria, Vol 34, Iss 3, Pp 271-280

Abstract Objective: To assess the prevalence, spirometry findings and risk factors for asthma in schoolchildren who were very low birth weight infants with and without bronchopulmonary dysplasia. Methods: Observational and cross-sectional study. The parents and/or tutors answered the International Study of Asthma and Allergies in Childhood questionnaire. The schoolchildren were submitted to the skin prick test and spirometry assessment. Results: 54 schoolchildren who were very low birth weight infants were assessed and 43 met the criteria for spirometry. Age at the assessment (bronchopulmonary dysplasia=9.5±0.85; without bronchopulmonary dysplasia=10.1±0.86 years) and birth weight (bronchopulmonary dysplasia=916.7±251.2; without bronchopulmonary dysplasia=1171.3±190.5g) were lower in the group with bronchopulmonary dysplasia (p<0.05). The prevalence of asthma among very low birth weight infants was 17/54 (31.5%), being 6/18 (33.3%) in the group with bronchopulmonary dysplasia. There was an association between wool blanket use in the first year of life (p=0.026) with the presence of asthma at school age. The skin prick test was positive in 13/17 (76.5%) and 23/37 (62.2%) of patients with and without asthma, respectively. The schoolchildren with asthma had lower z-score values of forced expiratory flow between 25% and 75% of forced vital capacity (n=16;−1.04±1.19) when compared to the group of patients without asthma (n=27;−0.380.93) (p=0.049). There was no difference between the spirometry variables in the groups regarding the presence or absence of bronchopulmonary dysplasia. Conclusions: Very low birth weight infants with and without bronchopulmonary dysplasia showed a high prevalence of asthma (33.3% and 30.6%, respectively). Pulmonary flow in the small airways was lower in children with asthma.