Advances in the imbalance of the immune microenvironment in the chronically photodamaged skin

In recent years, the mechanisms of repeated ultraviolet light (UV) radiation-induced spatial and temporal changes in the immune microenvironment and the imbalance are the hot research topic in the fields of skin, immunity, tumor and aging. Chronic UV radiation (UVR) can induce cellular phenotypic an...

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Main Authors: Xinling CHEN (Author), Yu SUN (Author), Yuhan JIANG (Author), Yue ZHENG (Author)
Format: Book
Published: editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology, 2023-12-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Xinling CHEN  |e author 
700 1 0 |a Yu SUN  |e author 
700 1 0 |a Yuhan JIANG  |e author 
700 1 0 |a Yue ZHENG  |e author 
245 0 0 |a Advances in the imbalance of the immune microenvironment in the chronically photodamaged skin 
260 |b editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology,   |c 2023-12-01T00:00:00Z. 
500 |a 1674-8468 
500 |a 10.3969/j.issn.1674-8468.2023.06.008 
520 |a In recent years, the mechanisms of repeated ultraviolet light (UV) radiation-induced spatial and temporal changes in the immune microenvironment and the imbalance are the hot research topic in the fields of skin, immunity, tumor and aging. Chronic UV radiation (UVR) can induce cellular phenotypic and functional changes in the skin microenvironment, and directly and indirectly alter the skin immune microenvironment. UVR induces immunosuppression, including activation of regulatory T cells and alterations in the number and function of antigen-presenting cells. The interactions among B cells, T cells, Langerhans cells and mast cells play an important role in UVR-induced immunosuppression. In addition, the effects of UVR on T cell co-inhibitory and co-stimulatory signals have been increasingly appreciated. In this paper, we review the recent progress in the imbalance of the immune microenvironment in the chronically photodamaged skin. 
546 |a ZH 
690 |a solar ultraviolet light 
690 |a immune microenvironment 
690 |a skin immunity 
690 |a tumor immunity 
690 |a photoaging 
690 |a Dermatology 
690 |a RL1-803 
655 7 |a article  |2 local 
786 0 |n Pifu-xingbing zhenliaoxue zazhi, Vol 30, Iss 6, Pp 529-533 (2023) 
787 0 |n http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2023.06.008 
787 0 |n https://doaj.org/toc/1674-8468 
856 4 1 |u https://doaj.org/article/b9da44c857a943f19cedb99837c194b9  |z Connect to this object online.