Locking up the AS1411 Aptamer with a Flanking Duplex: Towards an Improved Nucleolin-Targeting
We have designed AS1411-N6, a derivative of the nucleolin (NCL)-binding aptamer AS1411, by adding six nucleotides to the 5'-end that are complementary to nucleotides at the 3'-end forcing it into a stem-loop structure. We evaluated by several biophysical techniques if AS1411-N6 can adopt o...
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| Main Authors: | , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2021-02-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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