Interleukin-35 on B cell and T cell induction and regulation
Abstract Interleukin (IL)-35 is a relatively newly discovered member of IL-12 cytokine family that is unique in that it is a dimer formed by two subunits. The review documents the structure, secretion and signal transduction of IL-35, the regulation effect of IL-35 on B cells and T cells as well as...
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| Main Authors: | , , , , , |
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| Format: | Book |
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BMC,
2017-08-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_ba1cb2aaa4fe4124ae1ca019eb35782d | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Ai Huang |e author |
| 700 | 1 | 0 | |a Lin Cheng |e author |
| 700 | 1 | 0 | |a Miao He |e author |
| 700 | 1 | 0 | |a Jun Nie |e author |
| 700 | 1 | 0 | |a Jianjun Wang |e author |
| 700 | 1 | 0 | |a Ke Jiang |e author |
| 245 | 0 | 0 | |a Interleukin-35 on B cell and T cell induction and regulation |
| 260 | |b BMC, |c 2017-08-01T00:00:00Z. | ||
| 500 | |a 10.1186/s12950-017-0164-5 | ||
| 500 | |a 1476-9255 | ||
| 520 | |a Abstract Interleukin (IL)-35 is a relatively newly discovered member of IL-12 cytokine family that is unique in that it is a dimer formed by two subunits. The review documents the structure, secretion and signal transduction of IL-35, the regulation effect of IL-35 on B cells and T cells as well as the adoptive transfer of IL-35+ regulatory B cells (Breg), therapeutic prospects of recombinant IL-35 (rIL-35) and IL-35 regulation role in various diseases. B-cell regulation expands the regulatory range of IL-35 and alters the view that IL-10 is the chief immune mechanism for Breg cells which secrete IL-35. IL-35 induces Breg cells, which then can induce Treg cells. IL-35 also plays an immunomodulatory role in the human body. | ||
| 546 | |a EN | ||
| 690 | |a Interleukin −35 | ||
| 690 | |a B cells | ||
| 690 | |a T cells | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Inflammation, Vol 14, Iss 1, Pp 1-7 (2017) | |
| 787 | 0 | |n http://link.springer.com/article/10.1186/s12950-017-0164-5 | |
| 787 | 0 | |n https://doaj.org/toc/1476-9255 | |
| 856 | 4 | 1 | |u https://doaj.org/article/ba1cb2aaa4fe4124ae1ca019eb35782d |z Connect to this object online. |