Development of a 'drop-count' method for the screening of the ethanol content in hand sanitisers using oxalic acid and potassium permanganate titrimetry

• Main Authors: Kaneoa E. Monts'o (Author), Rapelang Ts'emane (Author), Teboho E. Mpakanyane (Author), Selloane C. Masiloane-Bohloko (Author), Thato V. Ramashamole (Author), Mosotho George (Author)
• Format: Book
• Published: Orapuh, Inc., 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.4314/orapj.v3i1.1; 2644-3740
• Keywords: COVID-19; drop-count; ethanol; hand sanitiser; oxalic acid; potassium permanganate; Internal medicine; RC31-1245; Medicine (General); R5-920
• Source: Orapuh Journal, Vol 3, Iss 1 (2022)

Introduction The demand for ethanol-based sanitisers has increased dramatically since the dawn of the COVID-19 era, making it very difficult for health regulators to ensure the quality of the products and the safety of unsuspecting consumers. This article reports the development and application of a simple 'drop-count' titrimetry method for the determination of ethanol in hand sanitisers. Materials and Methods This method follows the classical potassium permanganate-oxalic acid titrimetry but uses very small volumes of the reagents - 0.5 mL of ethanol sample solution, 6 mL of acidified 0.1 M potassium permanganate, and a few counted drops of 0.1M oxalic acid. Results This method achieved satisfactory figures of merit, namely, linearity (R2 ≥ 0.9667), reproducibility, and importantly very little matrix effect in the alcohol concentration range of 50 to 80%. Conclusion The small volumes (< 10 mL in total) of the reagents required make this method considerably safe and cost-effective and applicable for fieldwork even by untrained personnel, not just chemists as is often the case for field applications.