The ethical case for placebo control in HIV-cure-related studies with ART interruption

Many studies that seek to cure HIV must ask participants to interrupt their antiretroviral treatment. In such circumstances, is it permissible to include a placebo group in the study? We explain why doing so is a scientific and an ethical necessity, and more benign than imagined.

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Bibliographic Details
Main Authors: Monica Magalhaes (Author), Daniel R. Kuritzkes (Author), Nir Eyal (Author)
Format: Book
Published: Elsevier, 2022-09-01T00:00:00Z.
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Summary:Many studies that seek to cure HIV must ask participants to interrupt their antiretroviral treatment. In such circumstances, is it permissible to include a placebo group in the study? We explain why doing so is a scientific and an ethical necessity, and more benign than imagined.
Item Description:2055-6640
10.1016/j.jve.2022.100084