Pretreatment of alcoholic extract of Scrophularia Striata on spatial memory and lipid peroxidation in male rats during crystal meth addiction

• Main Authors: Somayyeh Hatami (Author), Homeira Hatami (Author), Farzam Sheikhzade (Author), Golamreza Dehgan (Author)
• Format: Book
• Published: Fasa University of Medical Sciences, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Background & Objective: Crystal meth damages the brain cells by inducing oxidative stress. In the present study the long- term injection effect of alcoholic extract of Scrophularia Striata on spatial memory and lipid peroxidation in male rats during crystal meth addiction was investigated.  Material & Methods: 49 male rats were divided in 7 groups including: control, sham (saline), crystal meth (5 mg/kg), Scrophularia Striata extract (100 and 200 mg/kg), pretreatment of Scrophularia Striata (100 mg/kg) + crystal meth (5 mg/kg), and pretreatment of Scrophularia Striata (200 mg/kg) + crystal meth (5 mg/kg).  Morris water maze test was used for assessing the spatial memory, and Malondialdehyde (MDA) was assayed as an index of lipid peroxidation. One-way analysis of variance (ANOVA) was used to analyze the data. Results: Spatial memory was significantly reduced by Crystal meth (P<0.001). Spatial memory was significantly improved by Scrophularia (100 and 200 mg/kg) in comparison to control group (P<0.05). Pretreatment of Scrophularia in both doses significantly improved the spatial memory in crystal meth group (P<0.05). MDA level significantly increased in crystal meth group (P<0.05), but pretreatment of Scrophularia significantly reduced the elevated level of MDA (P<0.05). Conclusion: It seems that, psychoactive drugs can impair spatial memory by inducing oxidative stress. Pretreatment of Scrophularia as an antioxidant, improves spatial memory which has been reduced by crystal meth.

Item Description

2228-5105
2783-1523