Synergy testing of FDA-approved drugs identifies potent drug combinations against Trypanosoma cruzi.

• Main Authors: Joseph D Planer (Author), Matthew A Hulverson (Author), Jennifer A Arif (Author), Ranae M Ranade (Author), Robert Don (Author), Frederick S Buckner (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

An estimated 8 million persons, mainly in Latin America, are infected with Trypanosoma cruzi, the etiologic agent of Chagas disease. Existing antiparasitic drugs for Chagas disease have significant toxicities and suboptimal effectiveness, hence new therapeutic strategies need to be devised to addres...