Naproxen-induced pseudolymphoma syndrome: a case report
Drug-induced pseudolymphoma syndrome is a rare form of adverse cutaneous drug reaction. Its clinical and histological presentation may mimic mycosis fungoides, which sometimes leads to misdiagnosis and unnecessary treatments. We describe the case of a 65-year-old man with a generalized pruritic and...
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| Main Authors: | , , , |
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| Format: | Book |
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Wolters Kluwer Medknow Publications,
2010-03-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_ba723b12080b4dfaa9cb3a49f4bd7b8a | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Shang-Hong Lin |e author |
| 700 | 1 | 0 | |a Cheng-Yu Wang |e author |
| 700 | 1 | 0 | |a Ji-Chen Ho |e author |
| 700 | 1 | 0 | |a Wei-Ming Wu |e author |
| 245 | 0 | 0 | |a Naproxen-induced pseudolymphoma syndrome: a case report |
| 260 | |b Wolters Kluwer Medknow Publications, |c 2010-03-01T00:00:00Z. | ||
| 500 | |a 1027-8117 | ||
| 500 | |a 10.1016/S1027-8117(10)60004-3 | ||
| 520 | |a Drug-induced pseudolymphoma syndrome is a rare form of adverse cutaneous drug reaction. Its clinical and histological presentation may mimic mycosis fungoides, which sometimes leads to misdiagnosis and unnecessary treatments. We describe the case of a 65-year-old man with a generalized pruritic and confluent maculopapular eruption. His history of skin lesions was concordant with medication and resolved after discontinuation. However, microscopic examination showed characteristic features of mycosis fungoides, including Pautrier-like microabscesses and cerebriform nuclei of atypical lymphocytes. The immunohistochemical study showed CD4/CD8 infiltrate ratio to be 1 in the epidermis. The histopathological result of a second skin biopsy was compatible with drug eruption. This experience demonstrates that combining clinical history, histological and immunohistochemical findings is crucial for a definite diagnosis of PLS. | ||
| 546 | |a EN | ||
| 690 | |a Maculopapular eruption | ||
| 690 | |a Naproxen | ||
| 690 | |a Pseudolymphoma syndrome | ||
| 690 | |a Dermatology | ||
| 690 | |a RL1-803 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Dermatologica Sinica, Vol 28, Iss 1, Pp 27-31 (2010) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1027811710600043 | |
| 787 | 0 | |n https://doaj.org/toc/1027-8117 | |
| 856 | 4 | 1 | |u https://doaj.org/article/ba723b12080b4dfaa9cb3a49f4bd7b8a |z Connect to this object online. |