Design and Synthesis of new Naproxen Analogues as Potential Anti-inflammatory Agents
4-aminobenzenesulfonamide derivatives were linked to α-carbon of naproxen a non-selective non-steroidal anti-inflammatory drug (NSAID) to increase its size, so; increase its selectivity toward COX-2 enzyme, rather than COX-1 enzyme, that lead to reduce gastrointestinal side effects of this drug. The...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Book |
| Published: |
College of Pharmacy / Mustansiriyah University,
2018-03-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | 4-aminobenzenesulfonamide derivatives were linked to α-carbon of naproxen a non-selective non-steroidal anti-inflammatory drug (NSAID) to increase its size, so; increase its selectivity toward COX-2 enzyme, rather than COX-1 enzyme, that lead to reduce gastrointestinal side effects of this drug. The chemical structures of the synthesized compounds and their intermediates were confirmed and characterized using elemental microanalysis (CHN), FTIR, and other physicochemical properties like melting points, Rf values. |
|---|---|
| Item Description: | 10.32947/ajps.v17i1.61 1815-0993 2959-183X |