Quantitative analysis of cryptic splicing associated with TDP-43 depletion
Abstract Background Reliable exon recognition is key to the splicing of pre-mRNAs into mature mRNAs. TDP-43 is an RNA-binding protein whose nuclear loss and cytoplasmic aggregation are a hallmark pathology in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). TDP-43 depletion cause...
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| Main Authors: | , , , , |
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| Format: | Book |
| Published: |
BMC,
2017-05-01T00:00:00Z.
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