Comparison of neuroprotective properties of the dipeptide mimetics of the 1st, 2nd and 4th loops of the brain-derived neurotrophic factor on the model oxidative stress in vitro
Resume. The purpose of this study was to compare neuroprotective properties of the dimeric dipeptide mimetics of the 1st, 2nd and 4th Loops of BDNF - GSB-214 (heptamethylenediamide bis-monosuccinyl-methionyl-serine), GTS-201 (hexamethylenediamide bis-hexanoyl-seryl-lysine) and GSB-106 (hexamethylene...
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| Main Authors: | , , , , , |
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| Format: | Book |
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LLC "Publisher OKI",
2019-10-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Resume. The purpose of this study was to compare neuroprotective properties of the dimeric dipeptide mimetics of the 1st, 2nd and 4th Loops of BDNF - GSB-214 (heptamethylenediamide bis-monosuccinyl-methionyl-serine), GTS-201 (hexamethylenediamide bis-hexanoyl-seryl-lysine) and GSB-106 (hexamethylenediamide bis-monosuccinyl-seryl-lysine) in the HT-22 hippocampal cells in conditions of oxidative stress. It has been established that the mimetic of the 4th loop of BDNF shows a neuroprotective effect in lower concentrations compared to mimetics based on the 1st and 2nd loops when applied 24 hours before and immediately after the damages. |
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| Item Description: | 2587-7836 2686-8830 10.24411/2587-7836-2018-10022. |