Comparison of neuroprotective properties of the dipeptide mimetics of the 1st, 2nd and 4th loops of the brain-derived neurotrophic factor on the model oxidative stress in vitro

• Main Authors: I. O. Logvinov (Author), A. V. Tarasiuk (Author), N. M. Sazonova (Author), P. I. Antipov (Author), T. A. Antipova (Author), T. A. Gudasheva (Author)
• Format: Book
• Published: LLC "Publisher OKI", 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2587-7836; 2686-8830; 10.24411/2587-7836-2018-10022.
• Keywords: нейропротекция; окислительный стресс; bdnf; димерные дипептидные миметики; гсб-214; гтс-201; гсб-106; neuroprotection; oxidative stress; bdnf; dimeric dipeptide mimetics; gsb-214; gts-201; gsb-106; Pharmacy and materia medica; RS1-441
• Source: Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 37-41 (2019)

Resume. The purpose of this study was to compare neuroprotective properties of the dimeric dipeptide mimetics of the 1st, 2nd and 4th Loops of BDNF - GSB-214 (heptamethylenediamide bis-monosuccinyl-methionyl-serine), GTS-201 (hexamethylenediamide bis-hexanoyl-seryl-lysine) and GSB-106 (hexamethylenediamide bis-monosuccinyl-seryl-lysine) in the HT-22 hippocampal cells in conditions of oxidative stress. It has been established that the mimetic of the 4th loop of BDNF shows a neuroprotective effect in lower concentrations compared to mimetics based on the 1st and 2nd loops when applied 24 hours before and immediately after the damages.