Cytotoxic Effect of the Her-2/Her-1 Inhibitor PKI-166 on Renal Cancer Cells Expressing the Connexin 32 Gene
We have reported that connexin (Cx) 32 acts as a tumor suppressor gene in renal cancer cells partly due to Her-2 inactivation. Here, we determined if a Her-2/Her-1 inhibitor (PKI-166) can enhance the tumor-suppressive effect of Cx32 in Caki-2 cells from human renal cell carcinoma. The expression of...
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| Main Authors: | , , , , , , , , , |
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Elsevier,
2005-01-01T00:00:00Z.
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| 001 | doaj_baa78f551d8843f99d8e6f5eb0484342 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Eriko Fujimoto |e author |
| 700 | 1 | 0 | |a Tomohiro Yano |e author |
| 700 | 1 | 0 | |a Hiromi Sato |e author |
| 700 | 1 | 0 | |a Kiyokazu Hagiwara |e author |
| 700 | 1 | 0 | |a Hiroshi Yamasaki |e author |
| 700 | 1 | 0 | |a Sumiko Shirai |e author |
| 700 | 1 | 0 | |a Keiko Fukumoto |e author |
| 700 | 1 | 0 | |a Hiromi Hagiwara |e author |
| 700 | 1 | 0 | |a Etsuko Negishi |e author |
| 700 | 1 | 0 | |a Koichi Ueno |e author |
| 245 | 0 | 0 | |a Cytotoxic Effect of the Her-2/Her-1 Inhibitor PKI-166 on Renal Cancer Cells Expressing the Connexin 32 Gene |
| 260 | |b Elsevier, |c 2005-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.scj04009x | ||
| 520 | |a We have reported that connexin (Cx) 32 acts as a tumor suppressor gene in renal cancer cells partly due to Her-2 inactivation. Here, we determined if a Her-2/Her-1 inhibitor (PKI-166) can enhance the tumor-suppressive effect of Cx32 in Caki-2 cells from human renal cell carcinoma. The expression of Cx32 in Caki-2 cells was required for PKI-166-induced cytotoxic effect at lower doses. The cyctotoxicity was dependent on the occurrence of apoptosis and partly mediated by Cx32-driven gap junction intercellular communications. These results suggest that PKI-166 further supports the tumor-suppressive effect of the Cx32 gene in renal cancer cells through the induction of apoptosis. Keywords:: connexin 32, PKI-166, renal cancer cell | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 97, Iss 2, Pp 294-298 (2005) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319322819 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/baa78f551d8843f99d8e6f5eb0484342 |z Connect to this object online. |