Cytotoxic Effect of the Her-2/Her-1 Inhibitor PKI-166 on Renal Cancer Cells Expressing the Connexin 32 Gene

• Main Authors: Eriko Fujimoto (Author), Tomohiro Yano (Author), Hiromi Sato (Author), Kiyokazu Hagiwara (Author), Hiroshi Yamasaki (Author), Sumiko Shirai (Author), Keiko Fukumoto (Author), Hiromi Hagiwara (Author), Etsuko Negishi (Author), Koichi Ueno (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have reported that connexin (Cx) 32 acts as a tumor suppressor gene in renal cancer cells partly due to Her-2 inactivation. Here, we determined if a Her-2/Her-1 inhibitor (PKI-166) can enhance the tumor-suppressive effect of Cx32 in Caki-2 cells from human renal cell carcinoma. The expression of...