Two Non-steroidal Anti-inflammatory Drugs, Niflumic Acid and Diclofenac, Inhibit the Human Glutamate Transporter EAAT1 Through Different Mechanisms
We investigated the effects of non-steroidal anti-inflammatory drugs on substrate-induced currents of l-glutamate (l-Glu) transporter EAAT1 expressed in Xenopus laevis oocytes. Niflumic acid (NFA) and diclofenac inhibited l-Glu-induced current through EAAT1 in a noncompetitive manner. NFA produced a...
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| Format: | Book |
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Elsevier,
2010-01-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_bae2bf9eef364241b6d46e083b10ab9d | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Kanako Takahashi |e author |
| 700 | 1 | 0 | |a Reiko Ishii-Nozawa |e author |
| 700 | 1 | 0 | |a Kouichi Takeuchi |e author |
| 700 | 1 | 0 | |a Ken Nakazawa |e author |
| 700 | 1 | 0 | |a Kaoru Sato |e author |
| 245 | 0 | 0 | |a Two Non-steroidal Anti-inflammatory Drugs, Niflumic Acid and Diclofenac, Inhibit the Human Glutamate Transporter EAAT1 Through Different Mechanisms |
| 260 | |b Elsevier, |c 2010-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.09260SC | ||
| 520 | |a We investigated the effects of non-steroidal anti-inflammatory drugs on substrate-induced currents of l-glutamate (l-Glu) transporter EAAT1 expressed in Xenopus laevis oocytes. Niflumic acid (NFA) and diclofenac inhibited l-Glu-induced current through EAAT1 in a noncompetitive manner. NFA produced a leftward shift in reversal potential (Erev) of l-Glu-induced current and increased current amplitude at the potentials more negative than −100 mV. Diclofenac had no effects on E rev and inhibited the current amplitude to the same extent at all negative potentials. These results indicate that NFA and diclofenac inhibit the l-Glu-induced EAAT1 current via different mechanisms.[Supplementary methods and Figure: available only at http://dx.doi.org/10.1254/jphs.09260SC] Keywords:: l-glutamate transporter, niflumic acid, diclofenac | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 112, Iss 1, Pp 113-117 (2010) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319310643 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/bae2bf9eef364241b6d46e083b10ab9d |z Connect to this object online. |