Exogenous ketone therapy for heart failure: A review

Heart failure is of major clinical and economic importance and remains a major public health problem worldwide. Despite existing treatment approaches, morbidity and mortality in these patients remains high. The progression of heart failure is accompanied by an increase in the metabolism of ketone bo...

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Main Authors: Yulia O. Aksenova (Author), Yulia F. Osmolovskaya (Author), Igor V. Zhirov (Author), Allan G. Beniashvili (Author), Margarita A. Morozova (Author), Sergey N. Tereshchenko (Author)
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Published: ZAO "Consilium Medicum", 2023-05-01T00:00:00Z.
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100 1 0 |a Yulia O. Aksenova  |e author 
700 1 0 |a Yulia F. Osmolovskaya  |e author 
700 1 0 |a Igor V. Zhirov  |e author 
700 1 0 |a Allan G. Beniashvili  |e author 
700 1 0 |a Margarita A. Morozova  |e author 
700 1 0 |a Sergey N. Tereshchenko  |e author 
245 0 0 |a Exogenous ketone therapy for heart failure: A review 
260 |b ZAO "Consilium Medicum",   |c 2023-05-01T00:00:00Z. 
500 |a 2075-1753 
500 |a 2542-2170 
500 |a 10.26442/20751753.2023.1.202174 
520 |a Heart failure is of major clinical and economic importance and remains a major public health problem worldwide. Despite existing treatment approaches, morbidity and mortality in these patients remains high. The progression of heart failure is accompanied by an increase in the metabolism of ketone bodies. The use of exogenous ketones may become a new therapeutic approach to increase cardiac efficiency, reduce energy deficit and improve cardiac function in patients with heart failure. The review presents the available data on ketone body metabolism in patients with heart failure, preclinical and clinical studies demonstrating the beneficial effects of exogenous ketone therapy in animal models and human studies with heart failure, and describes the potential pros and cons of using this therapeutic approach. 
546 |a RU 
690 |a heart failure 
690 |a metabolism 
690 |a ketones 
690 |a ketone bodies 
690 |a β-hydroxybutyrate 
690 |a Medicine (General) 
690 |a R5-920 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Consilium Medicum, Vol 25, Iss 1, Pp 46-51 (2023) 
787 0 |n https://consilium.orscience.ru/2075-1753/article/viewFile/418841/124859 
787 0 |n https://doaj.org/toc/2075-1753 
787 0 |n https://doaj.org/toc/2542-2170 
856 4 1 |u https://doaj.org/article/bae9d01c5a034f1fb745d1a7452f455f  |z Connect to this object online.