Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study

• Main Authors: Aurelie Nguimmo-Metsadjio (Author), Barbara Atogho-Tiedeu (Author), Jean Jacques Noubiap (Author), Marie-Solange Evehe (Author), Rosine Djokam-Dadjeu (Author), Olivier Sontsa Donfack (Author), Dieudonne Nanfa (Author), Edith Pascale M. Mato (Author), Elvis Ndonwi Ngwa (Author), Magellan Guewo-Fokeng (Author), Priscille Pokam-Fosso (Author), Wilfred F. Mbacham (Author), Jean Claude Mbanya (Author), Eugene Sobngwi (Author)
• Format: Book
• Published: BMC, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Abstract Objective This study aimed at investigating the association between the rs7903146 (C/T) polymorphism of the TCF7L2 gene with obesity in a Cameroonian population. Method This was a case-control pilot study including 61 obese and 61 non-obese Cameroonian adults. Anthropometric indices of obesity, blood pressure, fasting blood glucose, and blood lipids were measured. The rs7903146 (C/T) polymorphism of the TCF7L2 gene was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and genotypes were correlated with clinical and biological parameters. Results The T allele was predominant in the study population with a frequency of 93%. No statistically significant difference was however observed between the genotypic (p = 0.50) and allelic frequencies (p = 0.58) of obese and non-obese subjects. Comparison of clinical and biochemical parameters of C allele carriers (CX = CC + CT) with those of TT genotype showed that there was no significant difference between the lipid profile of these two groups. Conclusion The rs7903146 (C/T) polymorphism of the TCF7L2 gene might not be associated with obesity in the Cameroonian population.

Item Description

10.1186/s41043-017-0087-z
2072-1315