Di-(2-ethylhexyl) Phthalate Limits the Lipid-Lowering Effects of Simvastatin by Promoting Protein Degradation of Low-Density Lipoprotein Receptor: Role of PPARγ-PCSK9 and LXRα-IDOL Signaling Pathways

• Main Authors: Bei-Chia Guo (Author), Ko-Lin Kuo (Author), Jenq-Wen Huang (Author), Chia-Hui Chen (Author), Der-Cherng Tarng (Author), Tzong-Shyuan Lee (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2023-02-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Dialysis prevents death from uremia in patients with end-stage renal disease (ESRD). Nevertheless, during hemodialysis, circulating levels of di-(2-ethylhexyl) phthalate (DEHP) are increased due to phthalates leaching from medical tubes. Statins are an effective therapy for reducing the risks associ...