Lung cancer, comorbidities, and medication: the infernal trio

Most patients with lung cancer are smokers and are of advanced age. They are therefore at high risk of having age- and lifestyle-related comorbidities. These comorbidities are subject to treatment or even polypharmacy. There is growing evidence of a link between lung cancer, comorbidities and medica...

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Main Authors: Hélène Pluchart (Author), Sébastien Chanoine (Author), Denis Moro-Sibilot (Author), Christos Chouaid (Author), Gil Frey (Author), Julie Villa (Author), Bruno Degano (Author), Matteo Giaj Levra (Author), Pierrick Bedouch (Author), Anne-Claire Toffart (Author)
Format: Book
Published: Frontiers Media S.A., 2024-02-01T00:00:00Z.
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100 1 0 |a Hélène Pluchart  |e author 
700 1 0 |a Hélène Pluchart  |e author 
700 1 0 |a Hélène Pluchart  |e author 
700 1 0 |a Sébastien Chanoine  |e author 
700 1 0 |a Sébastien Chanoine  |e author 
700 1 0 |a Sébastien Chanoine  |e author 
700 1 0 |a Denis Moro-Sibilot  |e author 
700 1 0 |a Denis Moro-Sibilot  |e author 
700 1 0 |a Denis Moro-Sibilot  |e author 
700 1 0 |a Christos Chouaid  |e author 
700 1 0 |a Christos Chouaid  |e author 
700 1 0 |a Gil Frey  |e author 
700 1 0 |a Julie Villa  |e author 
700 1 0 |a Bruno Degano  |e author 
700 1 0 |a Bruno Degano  |e author 
700 1 0 |a Bruno Degano  |e author 
700 1 0 |a Matteo Giaj Levra  |e author 
700 1 0 |a Matteo Giaj Levra  |e author 
700 1 0 |a Pierrick Bedouch  |e author 
700 1 0 |a Pierrick Bedouch  |e author 
700 1 0 |a Pierrick Bedouch  |e author 
700 1 0 |a Anne-Claire Toffart  |e author 
700 1 0 |a Anne-Claire Toffart  |e author 
700 1 0 |a Anne-Claire Toffart  |e author 
245 0 0 |a Lung cancer, comorbidities, and medication: the infernal trio 
260 |b Frontiers Media S.A.,   |c 2024-02-01T00:00:00Z. 
500 |a 1663-9812 
500 |a 10.3389/fphar.2023.1016976 
520 |a Most patients with lung cancer are smokers and are of advanced age. They are therefore at high risk of having age- and lifestyle-related comorbidities. These comorbidities are subject to treatment or even polypharmacy. There is growing evidence of a link between lung cancer, comorbidities and medications. The relationships between these entities are complex. The presence of comorbidities and their treatments influence the time of cancer diagnosis, as well as the diagnostic and treatment strategy. On the other hand, cancer treatment may have an impact on the patient's comorbidities such as renal failure, pneumonitis or endocrinopathies. This review highlights how some comorbidities may have an impact on lung cancer presentation and may require treatment adjustments. Reciprocal influences between the treatment of comorbidities and anticancer therapy will also be discussed. 
546 |a EN 
690 |a comorbidities 
690 |a lung cancer 
690 |a survival 
690 |a polypharmacy 
690 |a drug-drug interaction 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Frontiers in Pharmacology, Vol 14 (2024) 
787 0 |n https://www.frontiersin.org/articles/10.3389/fphar.2023.1016976/full 
787 0 |n https://doaj.org/toc/1663-9812 
856 4 1 |u https://doaj.org/article/bb23e6f3c8cf4b5998347bf1f9f10caa  |z Connect to this object online.