The development and validation of an analytical method for doxycycline quantification in human plasma - doi:10.5020/18061230.2007.p193

• Main Authors: Geysa Aguiar (Author), Eunice Kazue Kano (Author), Clarice Madalena Bueno Rolim (Author), Cristina Helena dos Reis Serra (Author), Humberto Gomes Ferraz (Author), Valentina Porta (Author)
• Format: Book
• Published: Universidade de Fortaleza, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to develop and validate a simple, quick and sensitive assay for determination of doxycycline concentration in human plasma by High Performance Liquid Chromatography (HPLC). Doxycycline and Oxytetracycline (internal standard) were extracted from 0,5 mL human plasma into ethy...