Investigating Dual-Species <i>Candida auris</i> and Staphylococcal Biofilm Antiseptic Challenge
<i>Candida auris</i> can persistently colonize human skin, alongside a diverse bacterial microbiome. In this study we aimed to investigate the efficacy of antiseptic activities on dual-species interkingdom biofilms containing staphylococci to determine if antiseptic tolerance was negativ...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2022-07-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | <i>Candida auris</i> can persistently colonize human skin, alongside a diverse bacterial microbiome. In this study we aimed to investigate the efficacy of antiseptic activities on dual-species interkingdom biofilms containing staphylococci to determine if antiseptic tolerance was negatively impacted by dual-species biofilms. Chlorhexidine, povidone iodine, and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), were able to significantly reduce biofilm viable cell counts following exposure at 2%, 10%, and 3%, respectively. Notably, H<sub>2</sub>O<sub>2</sub>-treated biofilms were able to significantly recover and considerably repopulate following treatment. Fortunately, inter-kingdom interactions in dual-species biofilms of <i>C. auris</i> and staphylococci did not increase the tolerance of <i>C. auris</i> against antiseptics in vitro. These data indicate mixed infections are manageable with chlorhexidine and povidone iodine, but caution should be exercised in the consideration of H<sub>2</sub>O<sub>2</sub>. |
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| Item Description: | 10.3390/antibiotics11070931 2079-6382 |