Genotypic Diversity Is Associated with Clinical Outcome and Phenotype in Cryptococcal Meningitis across Southern Africa.

• Main Authors: Mathew A Beale (Author), Wilber Sabiiti (Author), Emma J Robertson (Author), Karen M Fuentes-Cabrejo (Author), Simon J O'Hanlon (Author), Joseph N Jarvis (Author), Angela Loyse (Author), Graeme Meintjes (Author), Thomas S Harrison (Author), Robin C May (Author), Matthew C Fisher (Author), Tihana Bicanic (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cryptococcal meningitis is a major cause of mortality throughout the developing world, yet little is known about the genetic markers underlying Cryptococcal virulence and patient outcome. We studied a cohort of 230 Cryptococcus neoformans (Cn) isolates from HIV-positive South African clinical trial...