Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system.

• Main Authors: Yaneth Osorio (Author), Bruno L Travi (Author), Adam R Renslo (Author), Alex G Peniche (Author), Peter C Melby (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: New drugs are needed to treat visceral leishmaniasis (VL) because the current therapies are toxic, expensive, and parasite resistance may weaken drug efficacy. We established a novel ex vivo splenic explant culture system from hamsters infected with luciferase-transfected Leishmania dono...