Antimicrobial and Antifungal Activities of Terpene-Derived Palladium Complexes

• Main Authors: Olga Zalevskaya (Author), Yana Gur'eva (Author), Aleksandr Kutchin (Author), Karl A. Hansford (Author)
• Format: Book
• Published: MDPI AG, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3390/antibiotics9050277; 2079-6382
• Keywords: Pd(II) complexes; terpene ligands; antimicrobial; antifungal activities; Therapeutics. Pharmacology; RM1-950
• Source: Antibiotics, Vol 9, Iss 5, p 277 (2020)

In an era of multidrug-resistant bacterial infections overshadowed by a lack of innovation in the antimicrobial drug development pipeline, there has been a resurgence in multidisciplinary approaches aimed at tackling this global health problem. One such approach is to use metal complexes as a framework for new antimicrobials. Indeed, in this context, bismuth-, silver- and gold-derived compounds in particular have displayed demonstrable antimicrobial activity. In this work, we discuss the antimicrobial and antifungal activities of terpene-derived chiral palladium complexes against <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, <i>Klebsiella pneumoniae</i>, <i>Acinetobacter baumannii</i>, <i>Escherichia coli</i>, <i>Candida albicans</i>, and <i>Cryptococcus neoformans</i>. It was established that all studied coordination compounds of palladium were highly active antifungal drugs. In contrast, the subset of palladacycles possessing a palladium-carbon bond were only active against the Gram-positive bacterium <i>Staphylococcus aureus</i>. All compounds were inactive against the Gram-negative bacteria tested.