Protein Oxidation Biomarkers and Myeloperoxidase Activation in Cerebrospinal Fluid in Childhood Bacterial Meningitis

• Main Authors: Emilie Rugemalira (Author), Irmeli Roine (Author), Julia Kuligowski (Author), Ángel Sánchez-Illana (Author), José David Piñeiro-Ramos (Author), Sture Andersson (Author), Heikki Peltola (Author), Manuel Leite Cruzeiro (Author), Tuula Pelkonen (Author), Máximo Vento (Author)
• Format: Book
• Published: MDPI AG, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The immunological response in bacterial meningitis (BM) causes the formation of reactive oxygen and nitrogen species (ROS, RNS) and activates myeloperoxidase (MPO), an inflammatory enzyme. Thus, structural oxidative and nitrosative damage to proteins and DNA occurs. We aimed to asses these events in...