Discovery of Novel Coumarin-Schiff Base Hybrids as Potential Acetylcholinesterase Inhibitors: Design, Synthesis, Enzyme Inhibition, and Computational Studies

• Main Authors: Aso Hameed Hasan (Author), Faruq Azeez Abdulrahman (Author), Ahmad J. Obaidullah (Author), Hadil Faris Alotaibi (Author), Mohammed M. Alanazi (Author), Mahmoud A. Noamaan (Author), Sankaranarayanan Murugesan (Author), Syazwani Itri Amran (Author), Ajmal R. Bhat (Author), Joazaizulfazli Jamalis (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To discover anti-acetylcholinesterase agents for the treatment of Alzheimer's disease (AD), a series of novel Schiff base-coumarin hybrids was rationally designed, synthesized successfully, and structurally characterized using Fourier transform infrared (FTIR), Nuclear magnetic resonance (NMR),...