Avian Pathogenic <i>Escherichia coli</i>: An Overview of Infection Biology, Antimicrobial Resistance and Vaccination
Avian Pathogenic <i>Escherichia coli</i> (APEC) is an extraintestinal pathotype of <i>E. coli</i> that leads to a range of clinical manifestations, including respiratory, systemic and reproductive infections of chickens in both egg and meat production. Unlike most <i>E....
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| Main Authors: | , |
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| Format: | Book |
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MDPI AG,
2024-08-01T00:00:00Z.
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| Summary: | Avian Pathogenic <i>Escherichia coli</i> (APEC) is an extraintestinal pathotype of <i>E. coli</i> that leads to a range of clinical manifestations, including respiratory, systemic and reproductive infections of chickens in both egg and meat production. Unlike most <i>E. coli</i> pathotypes, APEC is not defined by specific virulence genes but rather is a collection of several distinct genotypes that can act as both primary and secondary pathogens leading to colibacillosis. Recent measures to reduce antimicrobials both as growth promoters and as flock-level therapeutics are considered to have led to increased numbers of animals affected. Nevertheless, antimicrobial resistance is a considerable problem in APEC, with resistance to third and fourth-generation cephalosporins via extended-spectrum beta-lactamases (ESBLs), fluoroquinolones and colistin seen as a particular concern. The need to control APEC without antimicrobial use at the flock level has seen an increased focus on vaccination. Currently, a few commercial vaccines are already available, and a range of approaches are being applied to develop new vaccines, and other controls, such as bacteriophage or probiotics, are attracting interest. The lack of a single defined APEC genotype presents challenges to these approaches. |
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| Item Description: | 10.3390/antibiotics13090809 2079-6382 |