"UPRegulation" of CD47 by the endoplasmic reticulum stress pathway controls anti-tumor immune responses
Abstract We recently demonstrated that targeting the unfolded protein response (UPR) protein GRP78 down-regulates CD47 expression, resulting in increased tumor macrophage infiltration and inhibited resistance to anti-estrogen therapy. We now show new data indicating that anti-estrogen therapy regula...
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| Main Authors: | , |
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| Format: | Book |
| Published: |
BMC,
2017-08-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Abstract We recently demonstrated that targeting the unfolded protein response (UPR) protein GRP78 down-regulates CD47 expression, resulting in increased tumor macrophage infiltration and inhibited resistance to anti-estrogen therapy. We now show new data indicating that anti-estrogen therapy regulates CD47 expression and implicates its ligand, thrombospondin-1, in regulation of tumor macrophage infiltration. Moreover, GRP78 and CD47 co-expression is associated with poor prognosis in breast cancer patients, suggesting the existence of crosstalk between UPR and immunity that regulates therapeutic responses in breast cancer. |
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| Item Description: | 10.1186/s40364-017-0105-8 2050-7771 |