Venlafaxine Improves the Cognitive Impairment and Depression-Like Behaviors in a Cuprizone Mouse Model by Alleviating Demyelination and Neuroinflammation in the Brain

• Main Authors: Yanbo Zhang (Author), Xiaoying Bi (Author), Olubunmi Adebiyi (Author), Junhui Wang (Author), Ali Mooshekhian (Author), Jacob Cohen (Author), Zelan Wei (Author), Fei Wang (Author), Xin-Min Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Growing evidence has implicated that myelin deficits and neuroinflammation are the coexisted pathological features that contribute to the mood swing and cognitive decline in major depressive disorder (MDD) and multiple sclerosis (MS). Therefore, attenuation of neuroinflammation and reduction of demy...