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Prevalence of Undernutrition Among Children and Adolescents with Cancer Living in Sub-Saharan African Countries: A Systematic Review and Meta-analysis

Objective . To systematically review studies to provide the pooled estimate of undernutrition among children and adolescents with cancer living in sub-Saharan African countries. Methods . The review followed the recommendations outlined in the PRISMA statement. Online searches were performed on elec...

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Main Authors: Berhanu Mengistu MSc (Author), Aysheshim Kassahun Belew MSc (Author), Lemlem Daniel Baffa MPH (Author), Elsa Awoke Fentie MPH (Author), Muluken Chanie Agimas MPH (Author), Ever Siyoum Shewarega MPH (Author), Esmael Ali Muhammed MSc (Author), Mekuriaw Nibret Aweke MPH (Author)
Format: Book
Published: SAGE Publishing, 2024-11-01T00:00:00Z.
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Summary:Objective . To systematically review studies to provide the pooled estimate of undernutrition among children and adolescents with cancer living in sub-Saharan African countries. Methods . The review followed the recommendations outlined in the PRISMA statement. Online searches were performed on electronic databases such as PubMed, Scopus, Embase, and Hinari; gray literature sources: such as Google, Google Scholar, and university repositories were also searched. A random effect model was used to drive the pooled prevalence, and was reported at a 95% Confidence Interval (CI). Heterogeneity was assessed using subgroup analysis and univariable meta-regression. The effect of each study on the overall prevalence was assessed using leave-one-out sensitivity analysis. In all the models, statistical significance was set at P -value <.05. Result . A total of 623 articles were identified, and 21 articles were retrieved for the final analysis. The overall pooled prevalence of undernutrition was 41.34% (95% CI: 31.64%, 51.04%). The highest prevalence of undernutrition was observed from studies that used Arm Muscle Area (AMC) for age to assess undernutrition: 61.66% (95% CI: 47.59%, 75.72%). The protocol for this review has been registered at PROSPERO (CRD42024510052). Conclusion . The prevalence of undernutrition in sub-Saharan African countries was considerably high. Therefore, policy directions and cost-effective approaches that sustainably address undernutrition among pediatric patients with cancers are needed.
Item Description:2333-794X
10.1177/2333794X241298807

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