Possible Involvement of Akt Activity in Endothelial Dysfunction in Type 2 Diabetic Mice

• Главные авторы: Yasuhiro Takenouchi (Автор), Tsuneo Kobayashi (Автор), Takayuki Matsumoto (Автор), Katsuo Kamata (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2008-01-01T00:00:00Z.
• Предметы: article
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We investigated the effects of chronic simvastatin treatment on the impaired endothelium-dependent relaxation seen in aortas from type 2 diabetic mice. Starting at 8 weeks of diabetes, simvastatin (10 mg/kg per day) was administered to diabetic mice for 4 weeks. The significantly elevated systolic b...