NVP-BEZ235 (Dactolisib) Has Protective Effects in a Transgenic Mouse Model of Alzheimer's Disease

• Main Authors: Paula Maria Quaglio Bellozi (Author), Giovanni Freitas Gomes (Author), Leonardo Rossi de Oliveira (Author), Isabella Guimarães Olmo (Author), Érica Leandro Marciano Vieira (Author), Fabíola Mara Ribeiro (Author), Bernd L. Fiebich (Author), Antônio Carlos Pinheiro de Oliveira (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD) is a neurodegenerative disease and the main cause of dementia. Its major symptom is memory loss, which is a result of neuronal cell death, which is accompanied by neuroinflammation. Some studies indicate the overactivation of the phosphatidylinositol 3-kinase (PI3K)/pro...