Biological activity of some novel synthesized 2-(4-methylbenzenesulphonamido)pentanedioic acid bis amide derivatives: <i>In vitro</i> and <i>in vivo</i> antineoplastic activity
In the present work few novel 2-(4-methylbenzenesulphonamido)pentanedioic acid bis amide derivatives and the basic compound 2-(4-methylphenylsulfonamido)pentanedioic acid have been synthesized, characterized and screened for their possible antineoplastic activity both in vitro and in vivo. The in vi...
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| Main Authors: | , , |
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| Format: | Book |
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Bangladesh Pharmacological Society,
2014-10-01T00:00:00Z.
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| Summary: | In the present work few novel 2-(4-methylbenzenesulphonamido)pentanedioic acid bis amide derivatives and the basic compound 2-(4-methylphenylsulfonamido)pentanedioic acid have been synthesized, characterized and screened for their possible antineoplastic activity both in vitro and in vivo. The in vitro activity was performed against five human cell lines like human breast cancer (MCF-7), leukemia (K-562), ovarian cancer (OVACAR-3), human colon adenocarcinoma (HT-29) and Human kidney carcinoma (A-498). The in vivo activity was performed in female swiss albino mice against Ehrlich ascites carcinoma (EAC). Among the synthesized compounds, ureide, anilide, p-nitoanilide and o-bromoanilide derivatives of 2-(4-methyl benzene sulphonyl)-pentanedioic acid bis amides showed encouraging activity in both the in vitro and in vivo compared to other compounds. |
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| Item Description: | 1991-0088 |