Association between Preoperative serum markers and Lymph Node Metastasis in Endometrioid Adenocarcinoma of Endometrium
Objectives: Serum markers play many roles in various cancers. Our aim is to investigate whether preoperative serum markers can be used for predicting lymph node (LN) metastasis in endometrioid adenocarcinoma of endometrium. Materials and Methods: Clinical characteristics of all patients with pure en...
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| Format: | Book |
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The Royal Thai College of Obstetricians and Gynaecologists,
2018-03-01T00:00:00Z.
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| Summary: | Objectives: Serum markers play many roles in various cancers. Our aim is to investigate whether preoperative serum markers can be used for predicting lymph node (LN) metastasis in endometrioid adenocarcinoma of endometrium. Materials and Methods: Clinical characteristics of all patients with pure endometrioid adenocarcinoma of endometrium who underwent complete surgical staging at Rajavithi hospital, between 1 January 2010 and 31 December 2014 were retrospectively reviewed. Preoperative serum markers including hemoglobin (Hb), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), multiplication of neutrophil and monocyte counts (MNM), platelet counts, mean platelet volume (MPV) and serum albumin levels were investigated. Sensitivity, specificity, positive predictive value, negative predictive value of serum markers to predict lymph node metastasis were evaluated.Results: Two hundred eighty-three patients who meet the study inclusion criteria were included. There were 40/283 (14.3%) of LN metastasis. LN metastasis was significantly associated with lower Hb level (p < 0.001) and higher NLR, PLR, MNM and platelet count (p = 0.018, p = 0.004, p = 0.008 and p = 0.03 respectively). The best cut off values to identify lymph node metastasis were 11.85 for Hb (72.5% sensitivity, 59.7% specificity), 2.29 for NLR (60.0% sensitivity, 61.7% specificity), 10.37 for PLR (67.5% sensitivity, 56% specificity), 0.0068 for MNM (70% sensitivity, 56% specificity) and 297,500 for platelet count (62.5% sensitivity, 57% specificity). Conclusion: Preoperative lower Hb level, higher NLR, PLR, MNM and platelet count were significantly related with lymph node metastasis. They could be used in clinical practice to rule in patients with low risk for LN metastasis without extra costs. |
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| Item Description: | https://doi.org/10.14456/tjog.2018.1 0857-6084 0857-6084 |