Hypoxia and Hypoxia-Inducible Factors in Lymphedema
Lymphedema is a chronic inflammatory disorder characterized by edema, fat deposition, and fibrotic tissue remodeling. Despite significant advances in lymphatic biology research, our knowledge of lymphedema pathology is incomplete. Currently, there is no approved pharmacological therapy for this debi...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
| Published: |
Frontiers Media S.A.,
2022-03-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Lymphedema is a chronic inflammatory disorder characterized by edema, fat deposition, and fibrotic tissue remodeling. Despite significant advances in lymphatic biology research, our knowledge of lymphedema pathology is incomplete. Currently, there is no approved pharmacological therapy for this debilitating disease. Hypoxia is a recognized feature of inflammation, obesity, and fibrosis. Understanding hypoxia-regulated pathways in lymphedema may provide new insights into the pathobiology of this chronic disorder and help develop new medicinal treatments. |
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| Item Description: | 1663-9812 10.3389/fphar.2022.851057 |