Forensic parameters and admixture in seven geographical regions of the Guerrero state (South, Mexico) based on STRs of the Globalfiler® kit

• Main Authors: José Alonso Aguilar-Velázquez (Author), Gorge Locia-Aguilar (Author), Briselda López-Saucedo (Author), Sandra Deheza-Bautista (Author), Alma Faviola Favela-Mendoza (Author), Héctor Rangel-Villalobos (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 0301-4460; 1464-5033; 10.1080/03014460.2019.1568548
• Keywords: mexican-mestizos; guerrero state; admixture; globalfiler; forensic genetics; Biology (General); QH301-705.5; Human anatomy; QM1-695; Physiology; QP1-981
• Source: Annals of Human Biology, Vol 45, Iss 6-8, Pp 524-530 (2018)

Background: New commercial STR kits have emerged with greater numbers of markers, which allows for obtaining stronger conclusions in forensic casework, which has been poorly studied in Mexico. Aim: To obtain forensic parameters and to analyse the genetic relationships, structure and admixture in seven geographic regions of Guerrero state (South, Mexico) based on the Globalfiler® kit. Subjects and methods: A total of 245 unrelated Mexican individuals from seven regions of the state of Guerrero were analysed with the Globalfiler® kit. Forensic parameters, pairwise comparisons, genetic distances, structure analysis and admixture levels were estimated. Results: Allele frequencies and forensic parameters of 22 STRs were estimated in this Mexican population sample. The combined power of exclusion and power of discrimination values were > 99.9999% and >99.99999999%, respectively. The Native American, European and African ancestries estimated in the Guerrero state population were 70.9%, 25.9% and 3.2%, respectively. Conclusion: Forensic validation of the Globalfiler® kit was performed in the Guerrero state population. The geographic isolation level seems to be the principal factor in defining genetic relationships and admixture among the Guerrero sub-populations. Despite the intrinsic limitations of STRs for admixture analysis, these results are very close to previous values based on AIMs and genome-wide SNPs.