Acute inflammation phase proteins in cases of IgE-mediated and IgE-independent atopic dermatitis

• Main Authors: A. V. Burdina (Author), V. N. Zorina (Author), N. G. Korotkiy (Author), T. V. Shkolnikova (Author), N. A. Zorin (Author)
• Format: Book
• Published: State Scientific Center of Dermatovenereology and Cosmetology, 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 0042-4609; 2313-6294; 10.25208/0042-4609-2014-0-4-35-39
• Keywords: атопический дерматит; патогенез; igę; а₂-макроглобулин; а₁-антитрипсин; лактоферрин; atopic dermatitis; pathogenesis; igę; a₂-macroglobulin; α₁-antitrypsin; lactoferrin; Dermatology; RL1-803
• Source: Vestnik Dermatologii i Venerologii, Vol 0, Iss 4, Pp 35-39 (2017)

Goal. To determine the blood serum level of α2-macroglobulin (α2-MG), α1-antitrypsin (α1-AT), lactoferrin (LF) and albumin in patients with IgE-mediated and IgE-independent atopic dermatitis (AD). Materials and methods. The authors tested blood serum of 60 adult patients suffering from atopic dermatitis at the exacerbation stage (30 patients with IgE-mediated and 30 patients with IgE-independent atopic dermatitis) and 20 healthy donors in order to determine the level of these proteins by rocket immunoelectrophoresis, enzyme-linked immunosorbent assay and immunoturbidimetry methods. Major results. The albumin level is reliably reduced in case of IgE-mediated AD while the LF and α1-AT levels are increased, and concentrations of LF α1-AT and a2-MG are increased as compared to healthy people. There are differences between the level of LF, α2-MG and α1-AT. There was a statistically significant correlation between the LF levels and SCORAD score in both forms, and α2-MG and α1-AT only in case of IgE-independent AD. Conclusion. These results confirm the difference in the roles of these polyfunctional proteins in the pathogenesis of IgE-mediated and IgE-independent AD.